Neutrophils play a central role in eliminating bacterial pathogens, but may also contribute to end-organ damage in sepsis.Interleukin-8 (IL-8), a key modulator of neutrophil function, signals through neutrophil specific surface receptors CXCR-1 and CXCR-2.In this study a mechanistic computational model was used to evaluate and deploy an extracorpor
Traditionally, interatomic potentials assume Disposable Masks local bond formation supplemented by long-range electrostatic interactions when necessary.This ignores intermediate-range multiatom interactions that arise from the relaxation of the electronic structure.Here, we present the multilayer atomic cluster expansion (ml-ACE) that includes coll
Abstract Background Glycolysis, a classic characteristic of cancer cells, can drive cancer progression by generating lactate, which play as a key immunosuppressive mediator.Currently, ubiquitin-specific proteases 5 (USP5) has been demonstrated to facilitate tumor cell survival in multiple myeloma (MM), whereas whether USP5 was involved in glycolysi
Introduction: Depression is a chronic mental disorder that causes changes in mood, thoughts, behavior and physical health.According to the World Health Organization (WHO) 350 million people worldwide are said to suffer from this mental disorder.This explains why antidepressants are widely used.Aim: The aim of this study was to analyze the use of an